생명과학과 교수 목록

교수정보의 상세 화면-2019
이름 이창한 학력 박사 전공 생명과학전공(과)
정보	연구실 : 원천관 202호 연구실번호 : 2621 이메일 : leec@ajou.ac.kr 연구관심분야 : 미생물 유전학 및 유전체학, 단백질 항상성, 생화학 홈페이지1 : https://sites.google.com/view/microbial-genetics-lab/
학력	졸업연도/학교/학위 2012.08 한국과학기술원 박사 졸업연도/학교/학위 2007.02 한국과학기술원 학사
경력	2021–현재: 아주대학교, 생명과학과, 조교수 2017–2020: University of Michigan, Howard Hughes Medical Institute (미국), 박사후연구원 2015: Heidelberg University (독일), 방문연구원 2013–2017: Karolinska Institute (스웨덴), 박사후연구원 2012–2013: KAIST, 박사후연구원
연구분야	단백질은 모든 생명현상에 직접적으로 관여하여 하기 때문에 세균 부터 사람에 이르기까지 모든 생명체의 생명유지에 필수적인 요소이다. 단백질은 외부 혹은 세포 내 다양한 스트레스로 부터 쉽게 변성 된다. 따라서 생명체는 정교한 샤페론 (chaperone) 시스템을 통하여 세포 내의 단백질을 보호하고 항상성을 유지한다. 본 연구실은 감염성 세균과 공생 세균에서 단백질 항상성 시스템을 단백질 안정성 센서, 유전학, 유전체적 기법을 이용하여 동정하고, 이를 통해 발굴된 샤페론 단백질의 분자적 기작을 유전학적, 생화학적으로 규명하는 것을 목표로 한다. 궁극적으로 본 연구를 통한 확립된 지식을 바탕으로, 단백질 항상성 시스템을 타겟으로한 세균의 생장과 감염성을 조절할 수 있는 물질 탐색과 기술개발을 수행하고자 한다.
논문 및 연구활동	연구활동(주요논문) [논문] 김현희, Kevin Wu, 이창한, Stress-Responsive Periplasmic Chaperones in Bacteria , FRONTIERS IN MOLECULAR BIOSCIENCES , pp.1 -14 (May, 2021) [논문] 이창한, Jens Klockgether, Sebastian Fischer, Burkhard Tümmler , Janja Trcek, Ute Römling, Why? - Successful Pseudomonas aeruginosa clones with a focus on clone C , FEMS MICROBIOLOGY REVIEWS , Vol.4 , No.66 , pp.740 -762 (Nov, 2020) [논문] 이창한, Dawid S Zyla, Kevin Wu, Patrick Betschinger, Rudi Glockshuber, James Bardwell, A metabolite binding protein moonlights as a bile-responsive chaperone. , EMBO JOURNAL (Oct, 2020) [논문] Kevin Wu, 이창한, Frederick Stull, James Bardwell, Protein folding while chaperone bound is dependent on weak interactions , NATURE COMMUNICATIONS , pp.4833 -4842 (Oct, 2019) [논문] 이창한, 김현희, Axel Mogk, Bernd Bukau, Heinrich Lünsdorf, Janja Trček, Jasmin Jäger, Kamila B. Franke, Lothar Jänsch, Manfred Nimtz, Shady Mansour Kamal, Ute Römling, Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , pp.273 -282 (Jan, 2018) 국제학술논문지 [논문] 함수정, 이창한, Exploring the impact of nucleic acids on protein stability in bacterialcell lysate , BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS , pp.130445 -130445 (Aug, 2023) [논문] 구희찬, 문성준, 정주원, 함수정, 김현희, 이창한, Temperature matters: bacterial response to temperature change , JOURNAL OF MICROBIOLOGY , pp.343 -357 (Apr, 2023) [논문] 김상하, 이창한, Optimization of transposon mutagenesis methods in Pseudomonas antarctica , Microorganisms , Vol.11 , pp.118 -118 (Jan, 2023) [논문] 김현희, 정주원, 이창한, A method to study α-synuclein toxicity and aggregation using a humanized yeast model , Jove-Journal of Visualized Experiments , Vol.189 (Nov, 2022) [논문] 김현희, 문성준, 함수정, Ute Romling, 이기현, 이창한, Cytoplasmic molecular chaperones in Pseudomonas species. , JOURNAL OF MICROBIOLOGY , Vol.60 , pp.1049 -1060 (Nov, 2022) [논문] Kevin Wu, Rishav Mitra, 이창한, James Bardwell, ATP-Independent Chaperones , ANNUAL REVIEW OF BIOPHYSICS , Vol.9 , No.51 , pp.409 -429 (May, 2022) [논문] 김현희, Kevin Wu, 이창한, Stress-Responsive Periplasmic Chaperones in Bacteria , FRONTIERS IN MOLECULAR BIOSCIENCES , pp.1 -14 (May, 2021) [논문] Shady Mansour Kamal, 이창한, Alberto J Martín-Rodríguez, Annika Cimdins-Ahne, Axel Mogk, Fengyang Li, Haleluya Tesfaye Wami , Heinrich Lünsdorf, Lena Meins, Panagiotis Katikaridis, Robert Afasizhev, Ulrich Dobrindt, Zaira Seferbekova, Ute Römling, A recently isolated human commensal Escherichia coli ST10 clone member mediates enhanced thermotolerance and tetrathionate respiration on a P1 phage-derived IncY plasmid , MOLECULAR MICROBIOLOGY , pp.255 -271 (Feb, 2021) [논문] 이창한, Jens Klockgether, Sebastian Fischer, Burkhard Tümmler , Janja Trcek, Ute Römling, Why? - Successful Pseudomonas aeruginosa clones with a focus on clone C , FEMS MICROBIOLOGY REVIEWS , Vol.4 , No.66 , pp.740 -762 (Nov, 2020) [논문] 이창한, Dawid S Zyla, Kevin Wu, Patrick Betschinger, Rudi Glockshuber, James Bardwell, A metabolite binding protein moonlights as a bile-responsive chaperone. , EMBO JOURNAL (Oct, 2020) [논문] Ying Liu, 이창한, Alexey Chernobrovkin, Chun-Chi Chen, Fengyang Li, Heike Bähre, Janja Trček, Rey-Ting Guo, Roman Zubarev, Ute Römling, A Cyclic di-GMP Network Is Present in Gram-Positive Streptococcus and Gram-Negative Proteus Species , ACS INFECTIOUS DISEASES , pp.2672 -2687 (Oct, 2020) [논문] Kevin Wu, 이창한, Frederick Stull, James Bardwell, Protein folding while chaperone bound is dependent on weak interactions , NATURE COMMUNICATIONS , pp.4833 -4842 (Oct, 2019) [논문] Shady Mansour Kamal, 이창한, Christian Giske, Janja Trček, Julien Deschamps, Lothar Jänsch, Luciana Dini, Manfred Nimtz, Morten Levin Rybtke, Romain Briandet, Stefanie Sperlein, Tim Tolker-Nielsen, Ute Römling, Two FtsH Proteases Contribute to Fitness and Adaptation of Pseudomonas aeruginosa Clone C Strains , FRONTIERS IN MICROBIOLOGY , pp.1372 -1381 (Jul, 2019) [논문] 이창한, Shady Mansour Kamal, Ute Römling, High frequency of double crossover recombination facilitates genome engineering in Pseudomonas aeruginosa PA14 and clone C strains , MICROBIOLOGY-SGM , pp.757 -760 (Jul, 2019) [논문] 이창한, 김현희, James Bardwell, Electrostatic interactions are important for chaperone–client interaction in vivo , MICROBIOLOGY-SGM , pp.992 -997 (Jul, 2018) [논문] 이창한, 김현희, Axel Mogk, Bernd Bukau, Heinrich Lünsdorf, Janja Trček, Jasmin Jäger, Kamila B. Franke, Lothar Jänsch, Manfred Nimtz, Shady Mansour Kamal, Ute Römling, Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , pp.273 -282 (Jan, 2018) [논문] 이창한, 박찬규, Bacterial Responses to Glyoxal and Methylglyoxal: Reactive Electrophilic Species , INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , pp.169 -180 (Jan, 2017) [논문] 이창한, 고창민, 권민석, 김도윤, 김동규, 김성훈, 김지연, 김지홍, 민혜영, 이기현, 이나영, 박찬규, Screening for Escherichia coli K-12 genes conferring glyoxal resistance or sensitivity by transposon insertions , FEMS MICROBIOLOGY LETTERS , pp.363 -370 (Aug, 2016) [논문] 이창한, EdvardWigren, HeinrichLünsdorf, Ute Römling, Protein homeostasis-more than resisting a hot bath. , CURRENT OPINION IN MICROBIOLOGY , pp.147 -154 (Apr, 2016) [논문] 이창한, 이정훈, 이주영, 박찬규, Characterization of the Escherichia coli YajL, YhbO and ElbB glyoxalases , FEMS MICROBIOLOGY LETTERS , pp.363 -369 (Feb, 2016) [논문] 이창한, Edvard Wigren, Heinrich Lunsdorf, Janja Trcek, Manfred Nimtz, Muhammad Sharif Hasni, Ute Curth, Verena Peters, Ylva Lindqvist, 김지홍, 박찬규, Ute Römling, A novel protein quality control mechanism contributes to heat shock resistance of worldwide-distributed Pseudomonas aeruginosa clone C strains. , ENVIRONMENTAL MICROBIOLOGY , Vol.17 , No.11 , pp.4511 -4526 (Nov, 2015) [논문] 이창한, Ojar Melefors, Verena Peters, Ute Römling, Draft Genome Sequence of Pseudomonas aeruginosa SG17M, an Environmental Isolate Belonging to Clone C, Prevalent in Patients and Aquatic Habitats. , GENOME ANNOUNCEMENTS , Vol.2 , No.2 , pp.1 -2 (Mar, 2014) [논문] 이창한, 김인숙, 박찬규, Glyoxal detoxification in Escherichia coli K-12 by NADPH dependent aldo-keto reductases. , JOURNAL OF MICROBIOLOGY , Vol.51 , No.4 , pp.527 -530 (Aug, 2013) [논문] 이창한, 박찬규, 신종철, Novel regulatory system nemRA-gloA for electrophile reduction in Escherichia coli K-12. , MOLECULAR MICROBIOLOGY , Vol.88 , No.2 , pp.395 -412 (Apr, 2013) [논문] 이창한, 박찬규, Mutations upregulating the flhDC operon of Escherichia coli K-12. , JOURNAL OF MICROBIOLOGY , Vol.51 , No.1 , pp.140 -144 (Feb, 2013) [논문] 이창한, 박찬규, Development of a suicidal vector-cloning system based on butanal susceptibility due to an expression of YqhD aldehyde reductase. , JOURNAL OF MICROBIOLOGY , Vol.50 , No.2 , pp.249 -255 (Apr, 2012) [논문] 권민석, 이창한, 이정훈, 박찬규, Genomic rearrangements leading to overexpression of aldo-keto reductase YafB of Escherichia coli confer resistance to glyoxal. , JOURNAL OF BACTERIOLOGY , Vol.194 , No.8 , pp.1979 -1988 (Apr, 2012) [논문] 이창한, 김인숙, 민범찬, 이강록, 이정훈, 박찬규, Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12. , JOURNAL OF BACTERIOLOGY , Vol.192 , No.16 , pp.4205 -4214 (Aug, 2010) [논문] 김인숙, 이창한, 김준호, 민범찬, 박찬규, Screening of genes related to methylglyoxal susceptibility , JOURNAL OF MICROBIOLOGY , pp.339 -343 (Aug, 2007) 국제학술발표 [학술회의] 이창한, Chaperone discovery , International Meeting of the Microbiological Society of Korea (Oct, 2022) [학술회의] 김현희, 이창한, Discovery of Anti-protein Aggregating Factors in Bacteria , International Meeting of the Microbiological Society of Korea (Oct, 2022) [학술회의] 함수정, 이창한, 김현희, The Role of Chaperones Encoded in the Transmissible Locus for Protein Quality Control , International Meeting of the Microbiological Society of Korea (Oct, 2022) [학술회의] 정주원, 이창한, 김현희, The Anti-aggregation Activity of OPE1 in Humanized Yeast Model to Study Neurodegenerative Diseases , International Meeting of the Microbiological Society of Korea (Oct, 2022) [학술회의] 문성준, 이창한, 김현희, Regulatory Mechanism of Diaggregating Chaperone ClpG in Pseudomonas aeruginosa , International Meeting of the Microbiological Society of Korea (Oct, 2022) 국내학술발표 [학술회의] 이창한, Protein folding sensor for studying neurodegenerative diseases , The 19th Protein Metabolism and Target Protein Degradation (Aug, 2022)

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